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PLS1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q14651 |
|---|---|
| Clone Names | 100405143 |
| Gene ID | 5357 |
|---|---|
| Other Names | Plastin-1, Intestine-specific plastin, I-plastin, PLS1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13147b was selected from the C-term region of PLS1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PLS1 |
|---|---|
| Function | Actin-bundling protein. In the inner ear, it is required for stereocilia formation. Mediates liquid packing of actin filaments that is necessary for stereocilia to grow to their proper dimensions. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q3V0K9}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q3V0K9} |
| Tissue Location | In small intestine, colon, and kidney; relatively lower levels of expression are detected in the lung and stomach |
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Provided below are standard protocols that you may find useful for product applications.
Background
Plastins are a family of actin-binding proteins that areconserved throughout eukaryote evolution and expressed in mosttissues of higher eukaryotes. In humans, two ubiquitous plastinisoforms (L and T) have been identified. The protein encoded bythis gene is a third distinct plastin isoform, which isspecifically expressed at high levels in the small intestine.Alternatively spliced transcript variants varying in the 5' UTR,but encoding the same protein, have been found for this gene. Apseudogene of this gene is found on chromosome 11.
References
Chafel, M.M., et al. Dev. Dyn. 203(2):141-151(1995)Lin, C.S., et al. Mol. Cell. Biol. 14(4):2457-2467(1994)Shibata, M., et al. J. Leukoc. Biol. 54(1):10-16(1993)Lin, C.S., et al. J. Biol. Chem. 268(4):2781-2792(1993)Zu, Y., et al. Biochemistry 29(4):1055-1062(1990)
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