NEURL3 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q96EH8 |
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Clone Names | 110111022 |
Gene ID | 93082 |
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Other Names | E3 ubiquitin-protein ligase NEURL3, 632-, Lung-inducible neuralized-related C3CH4 RING domain protein, Neuralized-like protein 3, NEURL3, LINCR |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13218b was selected from the C-term region of NEURL3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | NEURL3 |
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Synonyms | LINCR |
Function | E3 ubiquitin-protein ligase that plays a role in various biological processes such as lung development or innate immunity (PubMed:30111563). Seems to utilize UBE2E1. Promotes innate antiviral response by catalyzing 'Lys-63'-linked ubiquitination of IRF7 (PubMed:35792897). Inhibits also hepatitis C virus assembly by directly binding to viral E1 envelope glycoprotein to disrupt its interaction with E2 (PubMed:30111563). |
Cellular Location | Cytoplasm |
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Provided below are standard protocols that you may find useful for product applications.
Background
E3 ubiquitin-protein ligase. It seems to utilize UBE2E1. In vitro, generates polyubiquitin chains via non-canonical lysine residues suggesting that it is not involved in tagging substrates for proteosomal degradation (By similarity).
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