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GPHB5 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q86YW7
Clone Names 100406015
Additional Information
Gene ID 122876
Other Names Glycoprotein hormone beta-5, Thyrostimulin subunit beta, GPHB5, GPB5, ZLUT1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13233b was selected from the C-term region of GPHB5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPHB5
Synonyms GPB5, ZLUT1
Function Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism.
Cellular Location Secreted.
Tissue Location Highly expressed in brain and at low levels in pituitary. Also found in retina, testis and skin but not in pancreas, parotid, kidney, stomach, liver, colon, small intestine, thyroid, brain or adrenal gland. In pituitary, colocalizes with ACTH, suggesting that it is located in corticotrophs.
Research Areas
Citations (0)
citation

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Background

GPHB5 is a cystine knot-forming polypeptide and a subunitof the dimeric glycoprotein hormone family (Hsu et al., 2002[PubMed 12089349]).

References

Suzuki, C., et al. Endocrinology 150(5):2237-2243(2009)Okajima, Y., et al. Regul. Pept. 148 (1-3), 62-67 (2008) :Okada, S.L., et al. Mol. Endocrinol. 20(2):414-425(2006)Sudo, S., et al. Endocrinology 146(8):3596-3604(2005)Heilig, R., et al. Nature 421(6923):601-607(2003)

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$ 277.78
Cat# BP13233b
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Availability: 2 weeks
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