|Other Names||N-acetylserotonin O-methyltransferase-like protein, ASMTL, 211-, ASMTL|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13236c was selected from the Center region of ASMTL. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219). In addition, the presence of the putative catalytic domain of S-adenosyl-L- methionine binding in the C-terminal region argues for a methyltransferase activity (Probable).|
|Tissue Location||Widely expressed. In adult, highly expressed in pancreas, placenta, fibroblast, thymus, prostate, testis, ovary and colon. Expressed at lower levels in spleen, small intestine and leukocytes. In fetus, expressed at high levels in the lung and kidney and at lower level in brain and liver|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene has an N-terminus that issimilar to the multicopy associated filamentation (maf) protein ofBacillus subtilis and to orfE of Escherichia coli, while theC-terminus is similar to N-acetylserotonin O-methyltransferase.This gene is located in the pseudoautosomal region 1 (PAR1) of Xand Y chromosomes. Three transcript variants encoding differentisoforms have been found for this gene.
Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Ried, K., et al. Hum. Mol. Genet. 7(11):1771-1778(1998)
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