|Other Names||WD repeat domain phosphoinositide-interacting protein 3, WIPI-3, WD repeat-containing protein 45-like, WDR45-like protein, WD repeat-containing protein 45B, WIPI49-like protein, WDR45B, WDR45L, WIPI3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13252a was selected from the N-term region of WDR45L. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:28561066). Binds phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2 (PubMed:28561066). In the cellular response to starvation, may also function together with the TSC1-TSC2 complex and RB1CC1 in the inhibition of the mTORC1 signaling pathway (PubMed:28503735).|
|Cellular Location||Preautophagosomal structure. Lysosome|
|Tissue Location||Ubiquitously expressed. Highly expressed in heart, skeletal muscle and pancreas. Up-regulated in a variety of tumor tissues including ovarian and uterine cancers|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the WIPI or SVP1 family ofWD40 repeat-containing proteins. The protein contains seven WD40repeats that are thought to fold into a beta-propeller structurethat mediates protein-protein interactions, and a conserved motiffor interaction with phospholipids. The human genome containsseveral pseudogenes of this gene.
Proikas-Cezanne, T., et al. Oncogene 23(58):9314-9325(2004)Jeffries, T.R., et al. Mol. Biol. Cell 15(6):2652-2663(2004)Venter, J.C., et al. Science 291(5507):1304-1351(2001)
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