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WDR45L Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q5MNZ6
Clone Names 100406308
Additional Information
Gene ID 56270
Other Names WD repeat domain phosphoinositide-interacting protein 3, WIPI-3, WD repeat-containing protein 45-like, WDR45-like protein, WD repeat-containing protein 45B, WIPI49-like protein, WDR45B, WDR45L, WIPI3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13252a was selected from the N-term region of WDR45L. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name WDR45B
Synonyms WDR45L, WIPI3
Function Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:28561066). Binds phosphatidylinositol 3-phosphate (PtdIns3P), and other phosphoinositides including PtdIns(3,5)P2, forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2 (PubMed:28561066, PubMed:30797857). In the cellular response to starvation, may also function together with the TSC1-TSC2 complex and RB1CC1 in the inhibition of the mTORC1 signaling pathway (PubMed:28503735).
Cellular Location Preautophagosomal structure. Lysosome
Tissue Location Ubiquitously expressed. Highly expressed in heart, skeletal muscle and pancreas. Up-regulated in a variety of tumor tissues including ovarian and uterine cancers
Research Areas
Citations (0)
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Background

This gene encodes a member of the WIPI or SVP1 family ofWD40 repeat-containing proteins. The protein contains seven WD40repeats that are thought to fold into a beta-propeller structurethat mediates protein-protein interactions, and a conserved motiffor interaction with phospholipids. The human genome containsseveral pseudogenes of this gene.

References

Proikas-Cezanne, T., et al. Oncogene 23(58):9314-9325(2004)Jeffries, T.R., et al. Mol. Biol. Cell 15(6):2652-2663(2004)Venter, J.C., et al. Science 291(5507):1304-1351(2001)

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$ 277.78
Cat# BP13252a
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