C17orf96 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | A6NHQ4 |
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Clone Names | 100408129 |
Gene ID | 100170841 |
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Other Names | Uncharacterized protein C17orf96, C17orf96 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13269c was selected from the Center region of C17orf96. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | EPOP (HGNC:34493) |
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Function | Scaffold protein that serves as a bridging partner between the PRC2/EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EZH2 complex. Interaction with USP7 promotes deubiquitination of H2B at promoter sites. Acts as a regulator of neuronal differentiation. |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q7TNS8}. Chromosome {ECO:0000250|UniProtKB:Q7TNS8}. Note=Localizes at both PRC2/EZH2 sites (H3K27me3) and broad H3K4me3 sites on chromatin of embryonic stem cells (ESCs). {ECO:0000250|UniProtKB:Q7TNS8} |
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Provided below are standard protocols that you may find useful for product applications.
Background
The specific function of this protein remains unknown.
References
Zody, M.C., et al. Nature 440(7087):1045-1049(2006)
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