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NETO2 Antibody (N-term ) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8NC67
Clone Names 100416042
Additional Information
Gene ID 81831
Other Names Neuropilin and tolloid-like protein 2, Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2, NETO2, BTCL2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13322a was selected from the N-term region of NETO2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NETO2
Synonyms BTCL2
Function Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein
Research Areas
Citations (0)
citation

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Background

This gene encodes a predicted transmembrane proteincontaining two extracellular CUB domains followed by a low-densitylipoprotein class A (LDLa) domain. It also has an intracellularFXNPXY-like motif, which has been shown in other proteins to beessential for the internalization of clathrin coated pits duringendocytosis. Alternatively spliced transcript variants have beenobserved, but they have not been fully characterized. [provided byRefSeq].

References

Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Stohr, H., et al. Gene 286(2):223-231(2002)

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$ 277.78
Cat# BP13322a
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Availability: 2 weeks
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