|Other Names||ELAV-like protein 3, Hu-antigen C, HuC, Paraneoplastic cerebellar degeneration-associated antigen, Paraneoplastic limbic encephalitis antigen 21, ELAVL3, HUC, PLE21|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13333a was selected from the N-term region of ELAVL3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance.|
|Tissue Location||Brain specific.|
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Provided below are standard protocols that you may find useful for product applications.
A member of the ELAVL protein family, ELAV-like 3 is aneural-specific RNA-binding protein which contains three RNP-typeRNA recognition motifs. The observation that ELAVL3 is one ofseveral Hu antigens (neuronal-specific RNA-binding proteins)recognized by the anti-Hu serum antibody present in sera frompatients with paraneoplastic encephalomyelitis and sensoryneuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Twoalternatively spliced transcript variants encoding distinctisoforms have been found for this gene.
Behrends, U., et al. Int. J. Cancer 100(6):669-677(2002)Park, S., et al. Mol. Cell. Biol. 20(13):4765-4772(2000)King, P.H. Nucleic Acids Res. 28 (7), E20 (2000) :Sakai, K., et al. Biochem. Biophys. Res. Commun. 256(2):263-268(1999)Van Tine, B.A., et al. Genomics 53(3):296-299(1998)
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