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ROBLD3 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9Y2Q5
Clone Names 100416161
Additional Information
Gene ID 28956
Other Names Ragulator complex protein LAMTOR2, Endosomal adaptor protein p14, Late endosomal/lysosomal Mp1-interacting protein, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2, Mitogen-activated protein-binding protein-interacting protein, MAPBP-interacting protein, Roadblock domain-containing protein 3, LAMTOR2, MAPBPIP, ROBLD3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13338c was selected from the Center region of ROBLD3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name LAMTOR2 (HGNC:29796)
Synonyms MAPBPIP, ROBLD3
Function As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:29123114, PubMed:29158492, PubMed:29107538, PubMed:28935770). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:30181260, PubMed:29123114, PubMed:29158492, PubMed:29107538, PubMed:28935770). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:22980980, PubMed:29123114, PubMed:29158492, PubMed:29107538). Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (By similarity).
Cellular Location Late endosome membrane {ECO:0000250|UniProtKB:Q9JHS3}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JHS3}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9JHS3}. Lysosome membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JHS3}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9JHS3}. Note=Recruited to lysosome and endosome membranes by LAMTOR1. {ECO:0000250|UniProtKB:Q9JHS3}
Research Areas
Citations (0)
citation

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Background

The product of this gene is highly conserved with a mouseprotein associated with the cytoplasmic face of late endosomes andlysosomes. The mouse protein interacts with MAPK scaffold protein1, a component of the mitogen-activated protein kinase pathway. Inhumans, a mutation in this gene has been associated with a primaryimmunodeficiency syndrome, and suggests a role for this protein inendosomal biogenesis. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].

References

Sancak, Y., et al. Cell 141(2):290-303(2010)Wunderlich, W., et al. J. Cell Biol. 152(4):765-776(2001)

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$ 277.78
Cat# BP13338c
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