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NDUFAF2 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8N183
Clone Names 100416171
Additional Information
Gene ID 91942
Other Names Mimitin, mitochondrial, B172-like, B172L, Myc-induced mitochondrial protein, MMTN, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2, NDUFA12-like protein, NDUFAF2, NDUFA12L
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13341c was selected from the Center region of NDUFAF2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NDUFAF2
Synonyms NDUFA12L
Function Acts as a molecular chaperone for mitochondrial complex I assembly (PubMed:16200211, PubMed:19384974). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:16200211, PubMed:27626371).
Cellular Location Mitochondrion.
Tissue Location Highly expressed in ESCC cells. Also expressed in heart, skeletal muscle, liver, and in fibroblasts
Research Areas
Citations (0)
citation

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Background

NADH:ubiquinone oxidoreductase (complex I) catalyzes thetransfer of electrons from NADH to ubiquinone (coenzyme Q) in thefirst step of the mitochondrial respiratory chain, resulting in thetranslocation of protons across the inner mitochondrial membrane.This gene encodes a complex I assembly factor. Mutations in thisgene cause progressive encephalopathy resulting from mitochondrialcomplex I deficiency.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Lesch, K.P., et al. Mol. Psychiatry (2010) In press :Herzer, M., et al. Neuropediatrics 41(1):30-34(2010)Hoefs, S.J., et al. Hum. Mutat. 30 (7), E728-E736 (2009) :Wang, L., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3558-3566(2008)

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$ 277.78
Cat# BP13341c
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Availability: 2 weeks
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