PDCL3 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9H2J4 |
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Clone Names | 100416196 |
Gene ID | 79031 |
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Other Names | Phosducin-like protein 3, HTPHLP, PhPL3, Viral IAP-associated factor 1, VIAF-1, PDCL3, PhLP2A, VIAF1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13347a was selected from the N-term region of PDCL3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PDCL3 |
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Synonyms | PhLP2A, VIAF1 |
Function | Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:23792958, PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (PubMed:17429077). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (PubMed:15371430). |
Cellular Location | Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum |
Tissue Location | Expressed in endothelial cells (at protein level) (PubMed:26059764). Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon (PubMed:15371430). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the phosducin-like proteinfamily and is a putative modulator of heterotrimeric G proteins.The protein shares extensive amino acid sequence homology withphosducin. Members of the phosducin-like protein family have beenshown to bind to the beta-gamma subunits of G proteins. [providedby RefSeq].
References
Stirling, P.C., et al. Mol. Biol. Cell 18(6):2336-2345(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Wilkinson, J.C., et al. J. Biol. Chem. 279(49):51091-51099(2004)Lopez, P., et al. J. Biol. Chem. 278(3):1751-1757(2003)
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