|Other Names||Patatin-like phospholipase domain-containing protein 1, 311-, PNPLA1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13348a was selected from the N-term region of PNPLA1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Lipid hydrolase. Important in the formation of the epidermal lipid barrier. Plays a role in glycerophospholipid metabolism.|
|Cellular Location||Cytoplasm. Note=Clearly distributed in the cytoplasm of keratinocytes|
|Tissue Location||Expressed in the digestive system. Expressed in the epidermis of skin keratinocytes. Strongly expressed in the granular layer. Expressed in the upper epidermis and eccrine sweat glands of the dermis and in the region of keratin filament bundles, which is more pronounced in upper epidermal layers and in the lower cornified layers.|
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Provided below are standard protocols that you may find useful for product applications.
Human patatin-like phospholipases, such as PNPLA1, havebeen implicated in regulation of adipocyte differentiation and havebeen induced by metabolic stimuli (Wilson et al., 2006 [PubMed16799181]).
Kienesberger, P.C., et al. J. Lipid Res. 50 SUPPL, S63-S68 (2009) :Johansson, L.E., et al. PLoS ONE 4 (4), E5327 (2009) :De Chaudhuri, S., et al. Environ. Health Perspect. 116(4):501-505(2008)Wilson, P.A., et al. J. Lipid Res. 47(9):1940-1949(2006)
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