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SLC25A24 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q6NUK1
Clone Names 100416297
Additional Information
Gene ID 29957
Other Names Calcium-binding mitochondrial carrier protein SCaMC-1, Mitochondrial ATP-Mg/Pi carrier protein 1, Mitochondrial Ca(2+)-dependent solute carrier protein 1, Small calcium-binding mitochondrial carrier protein 1, Solute carrier family 25 member 24, SLC25A24, APC1, MCSC1, SCAMC1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13357a was selected from the N-term region of SLC25A24. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC25A24 (HGNC:20662)
Function Electroneutral antiporter that mediates the transport of adenyl nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenyl nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide- dependent metabolic pathways (PubMed:15123600, PubMed:22015608). In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides (PubMed:15123600). May play a role in protecting cells against oxidative stress-induced cell death, by buffering calcium levels in the mitochondrial matrix through the formation of calcium- phosphate precipitates (PubMed:22015608, PubMed:29100093).
Cellular Location Mitochondrion inner membrane; Multi-pass membrane protein
Tissue Location Expressed in all tissues tested. Highly expressed in testis, expressed at intermediate level in small intestine and pancreas, and weakly expressed in kidney, spleen, liver, skeletal muscle and heart.
Research Areas
Citations (0)
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Background

Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria.

References

Rose, J. Phd, et al. Mol. Med. (2010) In press :Fiermonte, G., et al. J. Biol. Chem. 279(29):30722-30730(2004)del Arco, A., et al. J. Biol. Chem. 279(23):24701-24713(2004)

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$ 277.78
Cat# BP13357a
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