SLC25A24 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q6NUK1 |
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Clone Names | 100416297 |
Gene ID | 29957 |
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Other Names | Calcium-binding mitochondrial carrier protein SCaMC-1, Mitochondrial ATP-Mg/Pi carrier protein 1, Mitochondrial Ca(2+)-dependent solute carrier protein 1, Small calcium-binding mitochondrial carrier protein 1, Solute carrier family 25 member 24, SLC25A24, APC1, MCSC1, SCAMC1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13357a was selected from the N-term region of SLC25A24. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SLC25A24 (HGNC:20662) |
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Function | Electroneutral antiporter that mediates the transport of adenyl nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenyl nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide- dependent metabolic pathways (PubMed:15123600, PubMed:22015608). In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides (PubMed:15123600). May play a role in protecting cells against oxidative stress-induced cell death, by buffering calcium levels in the mitochondrial matrix through the formation of calcium- phosphate precipitates (PubMed:22015608, PubMed:29100093). |
Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein |
Tissue Location | Expressed in all tissues tested. Highly expressed in testis, expressed at intermediate level in small intestine and pancreas, and weakly expressed in kidney, spleen, liver, skeletal muscle and heart. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Fiermonte, G., et al. J. Biol. Chem. 279(29):30722-30730(2004)del Arco, A., et al. J. Biol. Chem. 279(23):24701-24713(2004)
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