Active Cathepsin D, Human Recombinant
Procathepsin D, CTSD
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P07339 |
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Calculated MW | 45.1 kDa |
Gene ID | 1509 |
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Other Names | Procathepsin D, CTSD |
Gene Source | Human |
Source | E. coli |
Assay&Purity | SDS-PAGE;≥80% |
Assay2&Purity2 | N/A;≥80% |
Recombinant | Yes |
Target/Specificity | Cathepsin D |
Application Notes | Reconstitute to 1 mg/ml in water |
Format | Freeze-Dried |
Storage | -20°C;Freeze-dried from proprietary buffer |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cathepsin D is a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is an estrogen-regulated protein associated with tissue breakdown. Levels of cathepsin D have been positively correlated with recurring breast cancers of both node negative and node positive types. Additionally cathepsin D has been associated with amyloid formation in Alzheimer’s plaques. Cathepsin D is produced initially as a pre-pro-enzyme which gets transported to lysosomes via endosomes in most cell types. In endosomes, it gets proteolyzed by unidentified proteases by removal of the pro-peptide to generate active single-chain Cathepsin D; while in lysosomes, further processing by cysteine cathepsins B and L generates mature, active double-chain Cathepsin D. BioVision’s Active Human Cathepsin D is a proteolytically active, non-glycosylated enzyme expressed, purified and activated by proprietary methods.
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