FAF1 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, IP |
---|---|
Primary Accession | Q9UNN5 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 73954 Da |
Gene ID | 11124 |
---|---|
Application & Usage | Western blotting (0.5-4 µg/ml) and in immunoprecipitation and Immunohistochemistry. However, the optimal conditions should be determined individually. Rat kidney cell lysate can be used as a positive control. |
Other Names | FAF1 (CT), Fas-associated protein 1, hFAF1, HFAF1s, TNFRSF6, TNFRSF6 associated factor 1 antibody, FAF1 |
Target/Specificity | FAF1 |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit anti-FAF1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | FAF1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | FAF1 |
---|---|
Synonyms | UBXD12, UBXN3A |
Function | Ubiquitin-binding protein (PubMed:19722279). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564). Potentiates but cannot initiate FAS-induced apoptosis (By similarity). |
Cellular Location | Nucleus. |
Tissue Location | Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes |
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Provided below are standard protocols that you may find useful for product applications.
Background
FAF1 (Fas-associated protein factor 1) specifically interacts with the cytoplasmic domain of wild type, but not mutated, Fas in both yeast and mammalian cells. When transiently expressed in T cells, FAF1 potentiates Fas-induced apoptosis. In contrast to TRADD, FADD, and RIP, FAF1 lacks a DDH (Death domain homologous region) and cannot induce apoptosis independent of Fas activation.
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