Cathepsin S Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, IP |
---|---|
Primary Accession | P25774 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 37496 Da |
Gene ID | 1520 |
---|---|
Positive Control | Western Blot: Jurkat cell lysate. IHC: Lung tissue |
Application & Usage | Western blotting (1-4 µg/ml), immunoprecipitation (20 µg/ml), and Immunohistochemistry (20 µg/ml). However, the optimal conditions should be determined individually. |
Other Names | CTSS, MGC3886 |
Target/Specificity | Cathepsin S |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit anti-cathepsin S polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | Cathepsin S Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CTSS |
---|---|
Function | Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation (PubMed:30612035). The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L. |
Cellular Location | Lysosome. Secreted. Cytoplasmic vesicle, phagosome |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cathepsin family of proteases contains several diverse classes of enzymes. The cysteine protease class comprises cathepsin B, H, K, L, O, and S. The aspartyl protease class contains cathepsin D and E. Cathepsin G belongs to the serine protease class. Cathepsins are involved in various cellular events such as peptide biosynthesis, protein degradation, and apoptosis. Cathepsin S has been shown to be present in aveloar macrophages.
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