PHOX2B Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q99453 |
Reactivity | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 31621 Da |
Gene ID | 8929 |
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Positive Control | Mouse liver tissue lysates |
Application & Usage | The antibody can be used for ELISA (1:1,000) and Western blotting (1: 100~500). |
Other Names | Neuroblastoma Phox, NBPhox |
Target/Specificity | PHOX2B |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | Supplied in PBS with 0.09% (W/V) sodium azide at a concentration of 0.25 mg/ml. This antibody is purified thro µgh a protein A column, followed by peptide affinity purification. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | PHOX2B Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PHOX2B |
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Synonyms | PMX2B |
Function | Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta- hydrolase and c-fos promoters, and of several enhancers including cAMP- response element and serum-response element. |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}. |
Tissue Location | Expressed in neuroblastoma, brain and adrenal gland |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper brain and sensory organ development and can cause epilepsy.
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