Glutathione Reductase Antibody (Clone 2B3)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E, IP |
---|---|
Primary Accession | P00390 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Isotype | Mouse IgG1 |
Clone Names | Clone 2B3 |
Calculated MW | 56257 Da |
Gene ID | 2936 |
---|---|
Positive Control | WB and IP: HeLa cell lysate |
Application & Usage | IP: 1-2 µl, ELISA. |
Other Names | GSR, GLUR, GRD1 |
Target/Specificity | Glutathione Reductase |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µl of antibody in HEPES with 0.15 M NaCl, 0.01 % BSA, 0.03 % sodium azide, and 50 % glycerol |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | Glutathione Reductase Antibody (Clone 2B3) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GSR |
---|---|
Synonyms | GLUR, GRD1 |
Function | Maintains high levels of reduced glutathione in the cytosol. |
Cellular Location | [Isoform Mitochondrial]: Mitochondrion. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Glutathione reductase (GR) is a member of pyridine nucleotide-disulfide oxidoreductases, which includes the closely related enzymes thioredoxin reductase, lipoamide dehydrogenase, trypanothione reductase and mercuric ion reductase. GR is a cytoplasmic flavoenzyme widely distributed in aerobic organisms. The dimeric protein is composed of two identical subunits, each containing 1 FAD and 1 redox-active disulfide/dithiol as components of the catalytic apparatus. It plays a role in maintaining glutathione (GSH) in its reduced form by catalyzing the reduction of glutathione disulfide (GSSG). In most eukaryotic cells, GR maintains the ratio of [GSH]/[GSSG] elevated, and participates in several vital functions such as the detoxification of reactive oxygen species as well as protein and DNA biosynthesis.
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