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SIAH3 Antibody
Purified Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q8IW03 |
| Other Accession | NP_001178047.1 |
| Reactivity | Human, Mouse, Rat, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 30660 Da |
| Gene ID | 283514 |
|---|---|
| Other Names | Seven in absentia homolog 3, Siah-3, SIAH3 |
| Target/Specificity | SIAH3 |
| Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit anti-SALL1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal. |
| Handling | The antibody solution should be gently mixed before use. |
| Background Descriptions | |
| Precautions | SIAH3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SIAH3 |
|---|---|
| Function | Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria. |
| Cellular Location | Mitochondrion. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SIAH-3 is a member of the seven in absentia homolog protein family. SIAH3 contains one SIAH-type zinc finger and is encoded by a gene located on human chromosome 13. SIAH families are components that mediate ubiquitination and subsequent proteasomal degradation of target proteins.
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