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Anti-Collagen-I Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, DB |
|---|---|
| Primary Accession | P02452 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 138911 Da |
| Gene ID | 1277 |
|---|---|
| Positive Control | Dot blot: rh collagen-I |
| Application & Usage | WB: 1-4 µg, Dot blot: 1-4 µg |
| Alias Symbol | COL1A1 |
| Other Names | Alpha-1 type I collagen, Collagen alpha-1(I) chain |
| Appearance | Colorless liquid |
| Formulation | In PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin® and 50 % glycerol |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Anti-Collagen-I Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | COL1A1 |
|---|---|
| Function | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| Cellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793} |
| Tissue Location | Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Collagen, a major component of the extracellular matrix, is a fibrous protein that provides tensile strength to tissues giving them structural integrity. Collagen and its derivative, gelatin, have been widely used in medical, pharmaceutical and consumer products for more than 100 years. Collagens are fibrous, extracellular matrix proteins with high tensile strength and are the major components of connective tissue, such as tendons and cartilage. All collagens contain a triple helix domain and frequently show lateral self-association in order to form complex connective tissues. Several collagens also play a role in cell adhesion, important for maintaining normal tissue architecture and function. The extensive family of COL gene products (collagens) is composed of several chain types, including fibril-forming interstitial collagens (types I, II, III and V) and basement membrane collagens (type IV), each type containing multiple isoforms.
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