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Anti-CNOT7 Antibody

     
  • WB - Anti-CNOT7 Antibody  ABV11966-100
    WB analysis of CNOT7 expression in HeLa (A); HuvEc (B); DKD (C); mouse brain (D); rat brain (E) whole cell lysates
    detail
  • IHC - Anti-CNOT7 Antibody  ABV11966-100
    Immunohistochemical analysis of CNOT7 staining In human ovarian cancer formalin fixed paraffin embedded tissue section.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IH
Primary Accession Q9UIV1
Reactivity Human, Mouse, Rat
Host Rabbit
Isotype Rabbit IgG
Calculated MW 32745 Da
Additional Information
Gene ID 29883
Positive Control WB: HeLa, HuvEc, DKD, mouse brain, rat brain lysates ; IHC: human ovarian cancer tissue
Application & Usage WB; 1:500 – 1:2000, IH; 1:50 – 1:200
Other Names CAF1, CCR4-NOT transcription complex subunit 7, BTG1-binding factor 1, CCR4-associated factor 1, CAF-1, Caf1a
Target/Specificity CNOT7
Antibody Form Liquid
Appearance Colorless liquid
Handling The antibody solution should be gently mixed before use
Reconstitution & Storage -20°C
Background Descriptions
PrecautionsAnti-CNOT7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CNOT7
Synonyms CAF1
Function Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate (PubMed:20634287, PubMed:31439799, PubMed:19276069). Its function seems to be partially redundant with that of CNOT8 (PubMed:19605561). Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:20634287, PubMed:31439799, PubMed:19276069). During miRNA- mediated repression the complex seems also to act as translational repressor during translational initiation (PubMed:20065043). Additional complex functions may be a consequence of its influence on mRNA expression (PubMed:23236473, PubMed:19276069). Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti- proliferative activity (PubMed:23236473, PubMed:19276069).
Cellular Location Nucleus. Cytoplasm, P-body {ECO:0000250|UniProtKB:Q60809}. Cytoplasm, Cytoplasmic ribonucleoprotein granule. Note=NANOS2 promotes its localization to P-body (By similarity). Recruited to cytoplasmic ribonucleoprotein membraneless compartments by CAPRIN1, promoting deadenylation of mRNAs (PubMed:31439799) {ECO:0000250|UniProtKB:Q60809, ECO:0000269|PubMed:31439799}
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Discontinued
Cat# ABV11966-100
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