Arhgef4 Antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q7TNR9 |
Other Accession | NM_183019, NP_898840 |
Reactivity | Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 57kDa |
Gene ID | 226970 |
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Alias Symbol | 9330140K16Rik, Asef, ENSMUSG00000070955 |
Other Names | Rho guanine nucleotide exchange factor 4, APC-stimulated guanine nucleotide exchange factor, Asef, Arhgef4, Kiaa1112 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Arhgef4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | Arhgef4 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Arhgef4 |
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Synonyms | Kiaa1112 |
Function | Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. |
Cellular Location | Cytoplasm. Note=Colocalized with APC in the synapse of olfactory glomerulus |
Tissue Location | Expressed in colon epithelial cells. Highly expressed in CNS, including hippocampus, olfactory bulb and cerebellum Expression is aberrantly enhanced in most colorectal tumors |
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Provided below are standard protocols that you may find useful for product applications.
References
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Okazaki N.,et al.DNA Res. 10:35-48(2003).
Okazaki N.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Kawasaki Y.,et al.Science 289:1194-1197(2000).
Kawasaki Y.,et al.EMBO Rep. 10:1355-1362(2009).
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