|Application ||IHC-P, ICC|
|Dilution||IHC-P (4-10 µg/ml)|
|Other Names||Retinoic acid-induced protein 3, G-protein coupled receptor family C group 5 member A, Orphan G-protein-coupling receptor PEIG-1, Retinoic acid-induced gene 1 protein, RAIG-1, GPRC5A, GPCR5A, RAI3, RAIG1|
|Target/Specificity||Human GPRC5A / RAI3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||GPRC5A / RAI3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPCR5A, RAI3, RAIG1|
|Function||Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218).|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Localized in perinuclear vesicles, probably Golgi- associated vesicles.|
|Tissue Location||Expressed at high level in fetal and adult lung tissues but repressed in most human lung cancers (PubMed:9857033, PubMed:18000218). Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal chord at low to moderate levels. Not detectable in fetal heart, brain, and liver and adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, and peripheral leukocytes. According to PubMed:10783259, expressed at low but detectable level in pancreas and heart.|
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Unknown. This G-protein coupled receptor could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. The comparable expression level in fetal lung and kidney with adult tissues suggests a possible role in embryonic development and maturation of these organs. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways.
Cheng Y.,et al.J. Biol. Chem. 273:35008-35015(1998).
Cafferata E.G.,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Braeuner-Osborne H.,et al.Genomics 65:121-128(2000).
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