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PTPRA / RPTP-Alpha Antibody (Cytoplasmic Domain)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P18433 |
| Reactivity | Human, Mouse, Rabbit, Hamster, Monkey, Pig, Horse, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 91kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 5786 |
|---|---|
| Other Names | Receptor-type tyrosine-protein phosphatase alpha, Protein-tyrosine phosphatase alpha, R-PTP-alpha, 3.1.3.48, PTPRA, PTPA, PTPRL2 |
| Target/Specificity | Human PTPRA. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | PTPRA / RPTP-Alpha Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PTPRA |
|---|---|
| Synonyms | PTPA, PTPRL2 |
| Function | Tyrosine protein phosphatase which is involved in integrin- mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P18052}. Note=Localizes to focal adhesion sites following integrin engagement. {ECO:0000250|UniProtKB:P18052} |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
Sap J.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:6112-6116(1990).
Kaplan R.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:7000-7004(1990).
Krueger N.X.,et al.EMBO J. 9:3241-3252(1990).
Ohagi S.,et al.Nucleic Acids Res. 18:7159-7159(1990).
Jirik F.R.,et al.FEBS Lett. 273:239-242(1990).
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