WRNIP1 / WHIP Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | Q96S55 |
Reactivity | Human, Mouse, Rat, Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 72kDa |
Dilution | ELISA (1:10000-1:40000), IHC-P (2.5 µg/ml), WB (1:500-1:2000) |
Gene ID | 56897 |
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Other Names | ATPase WRNIP1, 3.6.1.3, Werner helicase-interacting protein 1, WRNIP1 (HGNC:20876) |
Target/Specificity | An internal region of the WHIP1 protein. The immunogen sequence shows 100% homology to human WHIP1 (isoform 1) and WHIP2 (isoform 2) with predicted molecular weights of 72.2 kD and 69.5 kD, respectively. The immunogen sequence also shows 100% homolog ... |
Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
Precautions | WRNIP1 / WHIP Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | WRNIP1 (HGNC:20876) |
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Function | Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys- 63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS. |
Cellular Location | Nucleus. Cytoplasm. Note=Colocalizes with WRN in granular structures in the nucleus. |
Tissue Location | Ubiquitously expressed. |
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Background
Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis.
References
Kawabe Y.,et al.J. Biol. Chem. 276:20364-20369(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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