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SCO1 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IF - SCO1 Antibody (Internal) ALS11438
    Immunofluorescence of SCO1 in Human Brain cells with SCO1 antibody at 20 ug/ml.
    detail
  • WB - SCO1 Antibody (Internal) ALS11438
    Western blot of SCO1 in human brain tissue lysate with SCO1 antibody at (A) 0.5 and (B) 1 ug/ml.
    detail
  • IHC - SCO1 Antibody (Internal) ALS11438
    Anti-SCO1 antibody IHC of human brain, cortex.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession O75880
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 34kDa
Dilution IHC-P (2.5 µg/ml)
Additional Information
Gene ID 6341
Other Names Protein SCO1 homolog, mitochondrial, SCO1, SCOD1
Target/Specificity 19 amino acid peptide from near the center of human SCO1.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsSCO1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SCO1
Synonyms SCOD1
Function Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Not required for the synthesis of MT-CO2/COX2 but plays a crucial role in stabilizing MT- CO2/COX2 during its subsequent maturation. Involved in transporting copper to the Cu(A) site on MT-CO2/COX2 (PubMed:15659396, PubMed:16735468, PubMed:17189203, PubMed:19336478, PubMed:15229189). Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1 (By similarity).
Cellular Location Mitochondrion. Mitochondrion inner membrane; Single-pass membrane protein
Tissue Location Predominantly expressed in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain.
Research Areas
Citations (0)
citation

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Background

Thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copper into the active site of COX.

References

Petruzzella V.,et al.Genomics 54:494-504(1998).
Horvath R.,et al.Biochem. Biophys. Res. Commun. 276:530-533(2000).
Peng Y.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS11438
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