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FCER2 / CD23 Antibody (aa48-248)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E, IP |
|---|---|
| Primary Accession | P06734 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 36kDa |
| Dilution | IHC-P (5 µg/ml), IP (0.3-0.5 µg/10E6 cells), WB (0.5-2 µg/ml) |
| Gene ID | 2208 |
|---|---|
| Other Names | Low affinity immunoglobulin epsilon Fc receptor, BLAST-2, C-type lectin domain family 4 member J, Fc-epsilon-RII, Immunoglobulin E-binding factor, Lymphocyte IgE receptor, CD23, Low affinity immunoglobulin epsilon Fc receptor membrane-bound form, Low affinity immunoglobulin epsilon Fc receptor soluble form, FCER2, CD23A, CLEC4J, FCE2, IGEBF |
| Target/Specificity | Recombinant protein corresponding to amino acids 48 to 248 of human FCER2 |
| Reconstitution & Storage | +4°C, avoid freezing |
| Precautions | FCER2 / CD23 Antibody (aa48-248) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FCER2 |
|---|---|
| Synonyms | CD23A, CLEC4J, FCE2, IGEBF |
| Function | Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells. On B cells, initiates IgE-dependent antigen uptake and presentation to T cells (PubMed:2167225). On macrophages, upon IgE binding and antigen cross-linking induces intracellular killing of parasites through activation of L-Arginine- nitric oxide pathway (PubMed:7544003). |
| Cellular Location | Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor. Secreted. Note=Also exists as a soluble excreted form, sCD23 |
| Tissue Location | Detected in urine (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
References
Ikuta K.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:819-823(1987).
Kikutani H.,et al.Cell 47:657-665(1986).
Luedin C.,et al.EMBO J. 6:109-114(1987).
Grimwood J.,et al.Nature 428:529-535(2004).
Yokota A.,et al.Cell 55:611-618(1988).
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