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LRP1 / CD91 Antibody
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E, IP, IHC-Fr, Flo |
|---|---|
| Primary Accession | Q07954 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Calculated MW | 505kDa |
| Dilution | IHC-P (5-10 µg/ml) |
| Gene ID | 4035 |
|---|---|
| Other Names | Prolow-density lipoprotein receptor-related protein 1, LRP-1, Alpha-2-macroglobulin receptor, A2MR, Apolipoprotein E receptor, APOER, CD91, Low-density lipoprotein receptor-related protein 1 85 kDa subunit, LRP-85, Low-density lipoprotein receptor-related protein 1 515 kDa subunit, LRP-515, Low-density lipoprotein receptor-related protein 1 intracellular domain, LRPICD, LRP1, A2MR, APR |
| Target/Specificity | Recognizes human CD91, a type I membrane protein which is also known as the alpha 2 macroglobulin receptor (alpha 2 MR). Recognizes an epitope in the extracellular region of the 500kD alpha chain. |
| Reconstitution & Storage | Long term: Add glycerol (40-50%) -20°C; Short term: +4°C |
| Precautions | LRP1 / CD91 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LRP1 (HGNC:6692) |
|---|---|
| Synonyms | A2MR, APR |
| Function | Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed:11907044, PubMed:12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2- macroglobulin receptor (PubMed:26142438, PubMed:1702392). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed:32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:12888553). |
| Cellular Location | [Low-density lipoprotein receptor-related protein 1 85 kDa subunit]: Cell membrane; Single-pass type I membrane protein Membrane, coated pit [Low-density lipoprotein receptor-related protein 1 intracellular domain]: Cytoplasm Nucleus. Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. |
| Tissue Location | Most abundant in liver, brain and lung. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.
References
Herz J.,et al.EMBO J. 7:4119-4127(1988).
Van Leuven F.,et al.Genomics 24:78-89(1994).
Van Leuven F.,et al.Genomics 52:138-144(1998).
Scherer S.E.,et al.Nature 440:346-351(2006).
Kutt H.,et al.Biochim. Biophys. Acta 1009:229-236(1989).
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