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APOC1 / Apolipoprotein C I Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | P02654 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 9kDa |
| Dilution | ELISA (1:8000), IHC-P (3.75 µg/ml), |
| Gene ID | 341 |
|---|---|
| Other Names | Apolipoprotein C-I, Apo-CI, ApoC-I, Apolipoprotein C1, Truncated apolipoprotein C-I, APOC1 |
| Target/Specificity | Human APOC1 / Apolipoprotein CI. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | APOC1 / Apolipoprotein C I Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | APOC1 |
|---|---|
| Function | Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein. |
| Cellular Location | Secreted. |
| Tissue Location | Synthesized mainly in liver and to a minor degree in intestine. Also found in the lung and spleen |
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Provided below are standard protocols that you may find useful for product applications.
Background
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
References
Knott T.J.,et al.Nucleic Acids Res. 12:3909-3915(1984).
Lauer S.J.,et al.J. Biol. Chem. 263:7277-7286(1988).
Freitas E.M.,et al.DNA Seq. 9:89-100(1998).
Nickerson D.A.,et al.Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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