RANGAP1 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF |
---|---|
Primary Accession | P46060 |
Reactivity | Human, Xenopus |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 64kDa |
Dilution | IHC-P (1:100), WB (1:500-1:1000), |
Gene ID | 5905 |
---|---|
Other Names | Ran GTPase-activating protein 1, RanGAP1, RANGAP1, KIAA1835, SD |
Target/Specificity | Reacts with human & Xenopus RanGAP |
Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
Precautions | RANGAP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RANGAP1 |
---|---|
Synonyms | KIAA1835, SD |
Function | GTPase activator for RAN (PubMed:8146159, PubMed:8896452, PubMed:16428860). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:8896452, PubMed:27160050). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). |
Cellular Location | Cytoplasm. Nucleus, nucleoplasm. Nucleus envelope. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic during interphase Detected at the nuclear envelope during interphase (PubMed:11854305, PubMed:15037602). Targeted to the nuclear pores after sumoylation (PubMed:11854305). During mitosis, associates with mitotic spindles, but is essentially not detected at the spindle poles (PubMed:11854305, PubMed:15037602). Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase (PubMed:11854305). Mitotic location also requires sumoylation (PubMed:11854305). |
Tissue Location | Highly expressed in brain, thymus and testis. |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state.
References
Bischoff F.R.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:1749-1753(1995).
Nagase T.,et al.DNA Res. 8:85-95(2001).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Dunham I.,et al.Nature 402:489-495(1999).
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