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CLIP1 / CLIP-170 Antibody
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P30622 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 162kDa |
| Dilution | ELISA (1:8000), IHC-P (2.5 µg/ml), WB (1-3 µg/ml) |
| Gene ID | 6249 |
|---|---|
| Other Names | CAP-Gly domain-containing linker protein 1, Cytoplasmic linker protein 1, Cytoplasmic linker protein 170 alpha-2, CLIP-170, Reed-Sternberg intermediate filament-associated protein, Restin, CLIP1, CYLN1, RSN |
| Target/Specificity | Human CLIP1 / CLIP170. This antibody is expected to recognize both reported isoforms (NP_002947.1; NP_937883.1). |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | CLIP1 / CLIP-170 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CLIP1 |
|---|---|
| Synonyms | CYLN1, RSN |
| Function | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle. Note=Localizes to microtubule plus ends (PubMed:21646404, PubMed:17889670). Localizes preferentially to the ends of tyrosinated microtubules (By similarity). Accumulates in plasma membrane regions with ruffling and protrusions. Associates with the membranes of intermediate macropinocytic vesicles (PubMed:12433698) {ECO:0000250|UniProtKB:Q922J3, ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17889670, ECO:0000269|PubMed:21646404} |
| Tissue Location | Detected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells of Hodgkin disease |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking.
References
Bilbe G.,et al.EMBO J. 11:2103-2113(1992).
Pierre P.,et al.Cell 70:887-900(1992).
Sahin U.,et al.Blood 100:4139-4145(2002).
Choi J.H.,et al.EMBO Rep. 3:988-994(2002).
Olsen J.V.,et al.Cell 127:635-648(2006).
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