AG3 / AGR3 Antibody (clone AGR3.1)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, ICC, IHC-Fr |
---|---|
Primary Accession | Q8TD06 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | AGR3.1 |
Calculated MW | 19kDa |
Dilution | IHC-Fr (1 µg/ml), IHC-P (10 µg/ml), WB (1 µg/ml) |
Gene ID | 155465 |
---|---|
Other Names | Anterior gradient protein 3 homolog, AG-3, AG3, hAG-3, Breast cancer membrane protein 11, AGR3, BCMP11 |
Target/Specificity | The antibody AGR3.1 recognizes the epitope HETTDKNLS within the AGR3 (AG3) protein (19-20 kD); a secreted cytoplasmic protein which can serve as a marker of carcinogenesis. |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
Precautions | AG3 / AGR3 Antibody (clone AGR3.1) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | AGR3 |
---|---|
Synonyms | BCMP11, PDIA18 |
Function | Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells. |
Cellular Location | Endoplasmic reticulum. Note=Found in the cytoplasm, which could include the endoplasmic reticulum |
Tissue Location | Expressed in the lung, in the ciliated cells of the airway epithelium (PubMed:25751668). Expression increased with differentiation of airway epithelial cells (PubMed:25751668). Not detected in the mucous cells (PubMed:25751668). Expressed in ciliated cells in the oviduct (PubMed:26170690). Also detected in stomach, colon, prostate and liver (PubMed:25751668). Expressed in breast, ovary, prostate and liver cancer (PubMed:26170690). Expression is associated with the level of differentiation of breast cancer (at protein level) (PubMed:26170690). |
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Provided below are standard protocols that you may find useful for product applications.
References
Adam P.J.,et al.J. Biol. Chem. 278:6482-6489(2003).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Scherer S.W.,et al.Science 300:767-772(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).
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