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PDE9A Antibody (clone 1E1)

Mouse Monoclonal Antibody

     
  • IHC - PDE9A Antibody (clone 1E1) ALS14273
    Anti-PDE9A antibody IHC of human adrenal cortex.
    detail
  • IHC - PDE9A Antibody (clone 1E1) ALS14273
    Anti-PDE9A antibody IHC of human prostate, epithelium.
    detail
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O76083
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1E1
Calculated MW 68kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 5152
Other Names High affinity cGMP-specific 3', 5'-cyclic phosphodiesterase 9A, 3.1.4.35, PDE9A
Target/Specificity Human PDE9A
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsPDE9A Antibody (clone 1E1) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDE9A (HGNC:8795)
Function Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755, PubMed:21483814). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity).
Cellular Location [Isoform PDE9A1]: Cell projection, ruffle membrane. Cytoplasm, perinuclear region. Golgi apparatus. Endoplasmic reticulum. Cell membrane, sarcolemma [Isoform PDE9A3]: Cytoplasm. Endoplasmic reticulum
Tissue Location Expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood (PubMed:9624146). Highest levels in brain, heart, kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate (PubMed:12565835). In brain, present in the cortex, cerebellum, and subiculum (at protein level) (PubMed:22328573). In heart, primarily localizes to myocytes (PubMed:25799991).
Research Areas
Citations (0)
citation

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Background

Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.

References

Fisher D.A.,et al.J. Biol. Chem. 273:15559-15564(1998).
Guipponi M.,et al.Hum. Genet. 103:386-392(1998).
Rentero C.,et al.Biochem. Biophys. Res. Commun. 301:686-692(2003).
Wang P.,et al.Gene 314:15-27(2003).
Rentero C.,et al.BMC Mol. Biol. 7:39-39(2006).

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Discontinued
Cat# ALS14273
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