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KMT2D / MLL2 Antibody (N-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | O14686 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 593kDa |
| Dilution | ELISA (1:16000), IHC-P (3.75 µg/ml), |
| Gene ID | 8085 |
|---|---|
| Other Names | Histone-lysine N-methyltransferase 2D, Lysine N-methyltransferase 2D, 2.1.1.43, ALL1-related protein, Myeloid/lymphoid or mixed-lineage leukemia protein 2, KMT2D, ALR, MLL2, MLL4 |
| Target/Specificity | Human MLL2. The immunizing peptide was designed from NP_003473.1. Since then the sequence has changed in the databases and currently differs at two locations in NP_003473.3. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | KMT2D / MLL2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KMT2D |
|---|---|
| Synonyms | ALR, MLL2, MLL4 |
| Function | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:17500065). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in most adult tissues, including a variety of hematoipoietic cells, with the exception of the liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.
References
Prasad R.,et al.Oncogene 15:549-560(1997).
Scherer S.E.,et al.Nature 440:346-351(2006).
Goo Y.-H.,et al.Mol. Cell. Biol. 23:140-149(2003).
Olsen J.V.,et al.Cell 127:635-648(2006).
Mo R.,et al.J. Biol. Chem. 281:15714-15720(2006).
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