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CCP110 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - CCP110 Antibody (C-Terminus) ALS15620
    Anti-CCP110 antibody IHC staining of human testis.
    detail
  • IF - CCP110 Antibody (C-Terminus) ALS15620
    Immunofluorescence of CCP110 in rat colon tissue with CCP110 antibody at 20 ug/ml.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession O43303
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 113kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 9738
Other Names Centriolar coiled-coil protein of 110 kDa, Centrosomal protein of 110 kDa, CP110, Cep110, CCP110, CEP110, CP110, KIAA0419
Target/Specificity Human CCP110 / CP110. Two isoforms of CCP110 are known to exist; this antibody will only detect the longer isoform.
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsCCP110 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCP110
Synonyms CEP110, CP110, KIAA0419
Function Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545, PubMed:17681131, PubMed:23486064, PubMed:30375385, PubMed:35301795). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425).
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q7TSH4} Note=Recruited early and then associates with the growing distal tips Recruited to the mother centriole by KIF24 (PubMed:21620453). Removed from centrioles by TTBK2, leading to initiation of ciliogenesis and localizes only to the daughter centriole in ciliated cells. In cytotoxic T lymphocytes remains associated with the mother centriole during docking of the centrosome at the immunological synapse upon target contact (By similarity). Recruited at the distal end of the mother centriole by MPHOSPH9 (PubMed:30375385) {ECO:0000250|UniProtKB:Q7TSH4, ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:30375385}
Tissue Location Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.
Research Areas
Citations (0)
citation

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Background

Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2.

References

Ishikawa K.,et al.DNA Res. 4:307-313(1997).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Loftus B.J.,et al.Genomics 60:295-308(1999).
Martin J.,et al.Nature 432:988-994(2004).
Chen Z.,et al.Dev. Cell 3:339-350(2002).

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Discontinued
Cat# ALS15620
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