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C11orf2 / Fat-Free Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - C11orf2 / Fat-Free Antibody (C-Terminus) ALS15645
    Anti-C11orf2 / Fat-Free antibody IHC staining of human placenta.
    detail
  • WB - C11orf2 / Fat-Free Antibody (C-Terminus) ALS15645
    Western blot analysis of Fat Free in mouse brain tissue lysate with Fat Free antibody at 1 ug/ml.
    detail
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9UID3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 86kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 738
Other Names Vacuolar protein sorting-associated protein 51 homolog, Another new gene 2 protein, Protein fat-free homolog, VPS51, ANG2, C11orf2, C11orf3, FFR
Target/Specificity Human C11orf2 / Fat-Free. At least two alternatively spliced isoforms are known to exist; this antibody will detect both isoforms.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsC11orf2 / Fat-Free Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VPS51
Synonyms ANG2, C11orf2, C11orf3, FFR
Function Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome- derived carriers to the TGN (PubMed:20685960). Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061).
Cellular Location Golgi apparatus, trans-Golgi network. Recycling endosome. Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex (PubMed:25799061)
Research Areas
Citations (0)
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Background

Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi networkl (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN.

References

Lemmens I.H.,et al.Genomics 49:437-442(1998).
Lemmens I.H.,et al.Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
Wan D.,et al.Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
Taylor T.D.,et al.Nature 440:497-500(2006).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).

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Discontinued
Cat# ALS15645
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