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Rhodopsin / RHO Antibody (clone A531)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IHC-P, IF |
|---|---|
| Primary Accession | P08100 |
| Reactivity | Human, Mouse, Rat, Pig, Bovine |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | A531 |
| Calculated MW | 39kDa |
| Dilution | IF (1:1000), IHC (1:1000), IHC-P (10 µg/ml), WB (1:5000) , |
| Gene ID | 6010 |
|---|---|
| Other Names | Rhodopsin, Opsin-2, RHO, OPN2 |
| Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
| Precautions | Rhodopsin / RHO Antibody (clone A531) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RHO |
|---|---|
| Synonyms | OPN2 |
| Function | Photoreceptor required for image-forming vision at low light intensity (PubMed:8107847, PubMed:7846071). Required for photoreceptor cell viability after birth (PubMed:2215617, PubMed:12566452). Light- induced isomerization of the chromophore 11-cis-retinal to all-trans- retinal triggers a conformational change that activates signaling via G-proteins (PubMed:8107847, PubMed:28524165, PubMed:26200343, PubMed:28753425). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:28524165, PubMed:26200343). |
| Cellular Location | Membrane; Multi-pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia |
| Tissue Location | Rod shaped photoreceptor cells which mediate vision in dim light |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal.
References
Nathans J.,et al.Proc. Natl. Acad. Sci. U.S.A. 81:4851-4855(1984).
Suwa M.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Bennett J.,et al.Gene 167:317-320(1995).
Al-Maghtheh M.,et al.Hum. Mutat. 2:249-255(1993).
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