BCL3 / BCL-3 Antibody (aa2-13)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | P20749 |
Other Accession | 602 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 47584 Da |
Dilution | IHC-P (5 µg/ml), WB (1:1000), |
Gene ID | 602 |
---|---|
Other Names | BCL3, B-cell CLL/lymphoma 3, B-cell leukemia/lymphoma 3, B-cell lymphoma 3 protein, BCL-3, BCL4, D19S37, Proto-oncogene BCL3 |
Target/Specificity | This Polyclonal antibody is directed against human Bcl 3 protein. The product was purified from serum by protein A chromatography. Expect reactivity with human Bcl 3. Cross-reactivity with Bcl 3 from other sources has not been determined. |
Reconstitution & Storage | PBS, pH 7.4, 0.02% sodium azide. Store at -20°C for up to one year. |
Precautions | BCL3 / BCL-3 Antibody (aa2-13) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | BCL3 |
---|---|
Synonyms | BCL4, D19S37 |
Function | Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity). |
Cellular Location | Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Ubiquitination via 'Lys-63'- linked ubiquitin chains is required for nuclear accumulation |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).
References
Ohno H.,et al.Cell 60:991-997(1990).
McKeithan T.W.,et al.Genomics 24:120-126(1994).
Bours V.,et al.Cell 72:729-739(1993).
Heissmeyer V.,et al.EMBO J. 18:4766-4778(1999).
Dechend R.,et al.Oncogene 18:3316-3323(1999).
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