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DOC2A Antibody (aa233-246)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q14183 |
| Other Accession | 8448 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 43959 Da |
| Dilution | ELISA (1:16000), IHC-P (5 µg/ml), |
| Gene ID | 8448 |
|---|---|
| Other Names | DOC2A, DOC2, Doc2-alpha, Double C2-like domains, alpha |
| Target/Specificity | Human DOC2A. |
| Reconstitution & Storage | Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing. |
| Precautions | DOC2A Antibody (aa233-246) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DOC2A |
|---|---|
| Function | Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. |
| Cellular Location | Lysosome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Synapse, synaptosome |
| Tissue Location | Predominantly expressed in brain. Also expressed in testis. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.
References
Orita S.,et al.Biochem. Biophys. Res. Commun. 206:439-448(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Sakaguchi G.,et al.Biochem. Biophys. Res. Commun. 217:1053-1061(1995).
Mochida S.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:11418-11422(1998).
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