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ATP6V0A4 Antibody (aa53-295)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q9HBG4 |
| Other Accession | 50617 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 96386 Da |
| Dilution | IHC-P (7.5 µg/ml), WB (1:500 - 1:3000), |
| Gene ID | 50617 |
|---|---|
| Other Names | ATP6V0A4, ATP6N1B, Renal tubular acidosis, RTA1C, STV1, V-ATPase 116 kDa, V-ATPase alpha 4, RTADR, ATP6N2, RDRTA2, V-ATPase 116 kDa isoform a4, VPH1, VPP2 |
| Target/Specificity | Human ATP6V0A4 |
| Reconstitution & Storage | 0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. |
| Precautions | ATP6V0A4 Antibody (aa53-295) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ATP6V0A4 |
|---|---|
| Synonyms | ATP6N1B, ATP6N2 |
| Function | Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Involved in normal vectorial acid transport into the urine by the kidney (PubMed:10973252, PubMed:12414817). |
| Cellular Location | Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000250|UniProtKB:Q920R6}; Multi-pass membrane protein. Note=Localizes to the apical surface of alpha- intercalated cells in the cortical collecting ducts of the distal nephron (PubMed:10973252). Localizes to the basolateral surface of beta-intercalated cells in the cortical collecting ducts of the distal nephron (By similarity). {ECO:0000250|UniProtKB:Q920R6, ECO:0000269|PubMed:10973252} |
| Tissue Location | Expressed in adult and fetal kidney. Found in the inner ear. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Part of the proton channel of the V-ATPase that is involved in normal vectorial acid transport into the urine by the kidney.
References
Smith A.N.,et al.Nat. Genet. 26:71-75(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 424:157-164(2003).
Scherer S.W.,et al.Science 300:767-772(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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