CYR61 Antibody (aa47-332)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | O00622 |
Other Accession | 3491 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 42027 Da |
Dilution | IHC-P (10 µg/ml), |
Gene ID | 3491 |
---|---|
Other Names | CYR61, GIG1, IGFBP10, Protein CYR61, CCN family member 1, CCN1, IBP-10, IGF-binding protein 10, IGFBP-10, Protein GIG1 |
Target/Specificity | Human CYR61 |
Reconstitution & Storage | 0.1 M Tris-glycine, pH 7, 20% Glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. |
Precautions | CYR61 Antibody (aa47-332) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CCN1 (HGNC:2654) |
---|---|
Function | Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. |
Cellular Location | Secreted. |
Volume | 50 µl |
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Background
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
References
Jay P.,et al.Oncogene 14:1753-1757(1997).
Martinerie C.,et al.Mol. Pathol. 50:310-316(1997).
Albrecht C.,et al.J. Biol. Chem. 275:28929-28936(2000).
Kolesnikova T.V.,et al.Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
Bi A.B.,et al.Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
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