NOXO1 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | Q8NFA2 |
Other Accession | 124056 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 41253 Da |
Dilution | IHC-P (10 µg/ml), WB (1:500 - 1:3000), |
Gene ID | 124056 |
---|---|
Other Names | NOXO1, NADPH oxidase organizer 1, Nox-organizing protein 1, p41NOX, p41NOXA, p41NOXC, Regulatory protein P41NOX, Nox organizer 1, p41NOXB, SH3PXD5, SNX28 |
Target/Specificity | Human NOXO1 |
Reconstitution & Storage | 0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. |
Precautions | NOXO1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NOXO1 |
---|---|
Synonyms | P41NOX, SH3PXD5 |
Function | Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. |
Cellular Location | [Isoform 3]: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Isoform 3 associates with the plasma membrane in a lipid-dependent manner (PubMed:12716910) |
Tissue Location | Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon Isoform 1 is preferentially expressed in testis |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.
References
Banfi B.,et al.J. Biol. Chem. 278:3510-3513(2003).
Geiszt M.,et al.J. Biol. Chem. 278:20006-20012(2003).
Takeya R.,et al.J. Biol. Chem. 278:25234-25246(2003).
Cheng G.,et al.J. Biol. Chem. 279:4737-4742(2004).
Cheng G.,et al.Gene 356:118-126(2005).
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