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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-PRTN3 / Myeloblastin Antibody (aa28-248, clone 5B8)
Anti-PRTN3 / Myeloblastin Antibody (aa28-248, clone 5B8)
Mouse Anti Human Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P24158 |
| Predicted | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Clone Names | 5B8 |
| Calculated MW | 27807 Da |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 5657 |
|---|---|
| Alias Symbol | PRTN3 |
| Other Names | PRTN3, ACPA, Azurophil granule protein 7, C-ANCA antigen, CANCA, C-ANCA, AGP7, Leukocyte proteinase 3, MBN, Myeloblastin, NP-4, Neutrophil proteinase 4, NP4, p29, PR-3, Proteinase 3, MBT, Wegener autoantigen, PR3, Serine proteinase, neutrophil |
| Target/Specificity | Human PRTN3 / Proteinase 3 |
| Reconstitution & Storage | PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide Store at -20°C. Minimize freezing and thawing. |
| Precautions | Anti-PRTN3 / Myeloblastin Antibody (aa28-248, clone 5B8) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PRTN3 |
|---|---|
| Synonyms | MBN |
| Function | Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279). |
| Cellular Location | Cytoplasmic granule. Secreted. Cell membrane; Peripheral membrane protein; Extracellular side. Membrane raft; Peripheral membrane protein; Extracellular side. Note=Localizes predominantly to azurophil granules (primary secretory granules) in neutrophils (PubMed:2033050, PubMed:3198760, PubMed:7897245, PubMed:18462208) Secreted upon neutrophil stimulation by TNF-alpha, lipopolysaccharide (LPS), fMLP and CXCL8/IL8 or during neutrophil transmigration (PubMed:22266279, PubMed:28240246). Following secretion tethered to the cell membrane by CD177 (PubMed:18462208, PubMed:22266279) |
| Tissue Location | Expressed in polymorphonuclear leukocytes (at protein level) (PubMed:2033050, PubMed:7897245, PubMed:3198760) Expressed in neutrophils (at protein level) (PubMed:28240246, PubMed:18462208, PubMed:21193407, PubMed:22266279, PubMed:17244676) Expressed in differentiating neutrophils (PubMed:18462208) |
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$ 467.50
Cat# ALS17341
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