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> home > Products > Primary Antibodies > Signal Transduction > Anti-TXNDC1 / TMX1 Antibody (aa269-280)
Anti-TXNDC1 / TMX1 Antibody (aa269-280)
Goat Anti Human Polyclonal Antibody
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- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9H3N1 |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 31791 Da |
| Dilution | ELISA (1:64000), IHC-P (3.75 µg/ml), WB (1:64000, 0.01 - 0.03 µg/ml) |
| Gene ID | 81542 |
|---|---|
| Alias Symbol | TMX1 |
| Other Names | TMX1, TXNDC1, Thioredoxin domain-containing, TXNDC, PDIA11, Thioredoxin domain containing, TMX |
| Target/Specificity | Human TMX1 / TXNDC. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-TXNDC1 / TMX1 Antibody (aa269-280) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TMX1 {ECO:0000303|PubMed:37648867, ECO:0000312|HGNC:HGNC:15487} |
|---|---|
| Function | Thiredoxin domain-containing protein that participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions (PubMed:11152479, PubMed:37648867). Acts as a key inhibitor of the alternative triglyceride biosynthesis pathway by inhibiting the activity of TMEM68/DIESL at the endoplasmic reticulum, thereby restricting accumulation of triacylglycerol (PubMed:37648867). The alternative triglyceride biosynthesis pathway mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids (PubMed:37648867). Acts as a protein disulfide isomerase by catalyzing formation or reduction of disulfide bonds (PubMed:22228764, PubMed:29932915). Specifically mediates formation of disulfide bonds of transmembrane proteins at the endoplasmic reticulum membrane (PubMed:22228764). Involved in endoplasmic reticulum-associated degradation (ERAD) via its protein disulfide isomerase activity by acting on folding-defective polypeptides at the endoplasmic reticulum membrane (PubMed:29932915). Acts as a negative regulator of platelet aggregation following secretion in the extracellular space (PubMed:30425049). Acts as a regulator of endoplasmic reticulum- mitochondria contact sites via its ability to regulate redox signals (PubMed:27502484, PubMed:31304984). Regulates endoplasmic reticulum- mitochondria Ca(2+) flux (PubMed:27502484). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein. Mitochondrion membrane; Single-pass type I membrane protein. Secreted. Note=Predominantly found in the endoplasmic reticulum (PubMed:11152479). Secreted in the extracellular space following thrombin stimulation (PubMed:30425049). Localizes to mitochondria-associated endoplasmic reticulum membrane (MAM); palmitoylation is required for MAM localization (PubMed:22045338, PubMed:27502484, PubMed:31304984). |
| Tissue Location | Ubiquitous (PubMed:11152479). Highly expressed in kidney, liver, placenta and lung (PubMed:11152479) |
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