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Anti-KITLG / SCF Antibody
Goat Anti Human Polyclonal Antibody
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- CITATIONS
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- BACKGROUND
Application 
| WB, IHC-P, E, Neut |
|---|---|
| Primary Accession | P21583 |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 30899 Da |
| Dilution | ELISA (0.5 - 2 µg/ml), IHC-P (5 µg/ml), Neut (0.01 - 0.01 µg/ml), WB (0.1 - 0.2 µg/ml) |
| Gene ID | 4254 |
|---|---|
| Alias Symbol | KITLG |
| Other Names | KITLG, C-Kit ligand, KIT ligand, Kitl, KL-1, SHEP7, SF, Steel factor, Stem cell factor, SCF, FPH2, Mast cell growth factor, MGF |
| Target/Specificity | Human SCF |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-KITLG / SCF Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KITLG (HGNC:6343) |
|---|---|
| Synonyms | MGF, SCF |
| Function | Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. |
| Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein [Soluble KIT ligand]: Secreted. |
Research Areas
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Application Protocols
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