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Anti-KMT2D / MLL2 Antibody (clone 2E1)

Mouse Anti Human Monoclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O14686
Predicted Human
Host Mouse
Clonality Monoclonal
Isotype IgG2a,k
Clone Names 2E1
Calculated MW 593389 Da
Dilution ELISA, IHC-P (10 µg/ml), WB
Additional Information
Gene ID 8085
Alias Symbol KMT2D
Other Names KMT2D, AAD10, ALL1-related protein, KABUK1, KMS, Lysine N-methyltransferase 2D, MLL2, Kabuki make-up syndrome, ALR, CAGL114, KMT2B, Lysine N-methyltransferase 2B, TNRC21
Target/Specificity Human MLL2
Reconstitution & Storage Protein A purified
PrecautionsAnti-KMT2D / MLL2 Antibody (clone 2E1) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KMT2D
Synonyms ALR, MLL2, MLL4
Function Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:17500065). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732).
Cellular Location Nucleus.
Tissue Location Expressed in most adult tissues, including a variety of hematoipoietic cells, with the exception of the liver
Research Areas
Citations (0)
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Discontinued
Cat# ALS17993
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