Anti-UBR5 Antibody (aa14-63)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | O95071 |
Predicted | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 309352 Da |
Dilution | ELISA, IHC-P (1:50), WB |
Gene ID | 51366 |
---|---|
Alias Symbol | UBR5 |
Other Names | UBR5, DD5, EDD, HHYD, KIAA0896, Progestin-induced protein, Ubiquitin-protein ligase, EDD1, HYD, Progestin induced protein |
Target/Specificity | EDD antibody detects endogenous levels of EDD. |
Reconstitution & Storage | Immunoaffinity purified |
Precautions | Anti-UBR5 Antibody (aa14-63) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | UBR5 |
---|---|
Synonyms | EDD, EDD1, HYD, KIAA0896 |
Function | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. |
Cellular Location | Nucleus. |
Tissue Location | Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.