Uromucoid Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IHC-F, IF |
---|---|
Primary Accession | Q91X17 |
Reactivity | Rat, Cow |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 70845 Da |
Gene ID | 22242 |
---|---|
Other Names | Uromodulin, Tamm-Horsfall urinary glycoprotein, THP, Uromodulin, secreted form, Umod |
Dilution | WB=1:500-2000,Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,Flow Cyt=1 µg/Test,IF=1:100-500, |
Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
Name | Umod |
---|---|
Function | [Uromodulin]: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia. |
Cellular Location | [Uromodulin, secreted form]: Secreted. Note=Detected in urine |
Tissue Location | Detected in urine (secreted form). Detected in kidney thick ascending limb epithelial cells (at protein level) |
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