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HSV 1 Neurovirulence factor ICP34.5 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | P08353 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 27533 Da |
| Other Names | Neurovirulence factor ICP34.5, Infected cell protein 34.5, protein gamma(1)34.5, RL1, ICP34.5 |
|---|---|
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | RL1 |
|---|---|
| Synonyms | ICP34.5 |
| Function | Inhibits the establishment of the immune response and of the integrated stress response (ISR) in the infected cell (PubMed:15705855, PubMed:21622569). Plays essential roles in viral nuclear egress to mediate capsid transit across the nuclear membrane (By similarity). Facilitates nuclear egress cooperatively with host C1QBP and protein kinase C/PKC to induce lamin A/C phosphorylation and subsequent reorganization (By similarity). In turn, lamina disassembles and nuclear egress occurs (By similarity). Recruits the serine/threonine protein phosphatase PPP1CA/PP1-alpha to dephosphorylate the translation initiation factor EIF2S1/eIF-2alpha, thereby couteracting the host shutoff of protein synthesis involving double-stranded RNA-dependent protein kinase EIF2AK2/PKR (PubMed:21622569, PubMed:9023344). In turn, controls host IRF3 activation and subsequently inhibits host interferon response (By similarity). Controls the DNA sensing pathway by interacting with and inhibiting host STING/TMEM173 (By similarity). Also down-modulates the host MHC class II proteins cell surface expression (PubMed:12072498). Acts as a neurovirulence factor that has a profound effect on the growth of the virus in central nervous system tissue, by interacting with host BECN1 and thereby antagonizing the host autophagy response (By similarity). |
| Cellular Location | Host cytoplasm. Host nucleus. Host nucleus, host nucleolus. Virion. Note=At early times in infection, colocalizes with PCNA and replication proteins in the host cell nucleus, before accumulating in the host cytoplasm by 8 to 12 hours post-infection. |
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Application Protocols
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$ 385.00
Cat# AP59047
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