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SARS-CoV-2 (COVID-19) NSP15 Antibody
Infectious Disease, COVID-19
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P0DTC1 |
| Other Accession | 6VWW_B |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone Names | NSP15 |
| Calculated MW | 489989 Da |
| Application Notes | WB: 0.5-1 μg/mL Antibody validated: SARS-CoV-2 (COVID-19) NSP15 antibody can detect 2 ng of free peptide at 1 μg/mL in ELISA. It can detect SARS-CoV-2 NSP15 recombinant protein by ELISA and WB. All other applications and species not yet tested. |
| Gene ID | 43740578 |
|---|---|
| Other Names | Uridylate-specific endoribonuclease, NendoU, NSP15, Non-structure protein 15 |
| Reconstitution & Storage | SARS-CoV-2 (COVID-19) NSP15 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | SARS-CoV-2 (COVID-19) NSP15 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | R1A |
|---|---|
| Function | [Replicase polyprotein 1a]: Multifunctional protein involved in the transcription and replication of viral RNAs. Contains the proteinases responsible for the cleavages of the polyprotein. |
| Cellular Location | [Host translation inhibitor nsp1]: Host cytoplasm [Papain-like protease nsp3]: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes in virally-induced cytoplasmic double-membrane vesicles (DMV) [3C-like proteinase nsp5]: Host cytoplasm. Host Golgi apparatus [Non-structural protein 7]: Host cytoplasm, host perinuclear region {ECO:0000250|UniProtKB:P0C6X9}. Host cytoplasm. Host endoplasmic reticulum. Note=nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes. {ECO:0000250|UniProtKB:P0C6X9} [RNA-capping enzyme subunit nsp9]: Host cytoplasm, host perinuclear region {ECO:0000250|UniProtKB:P0C6X9}. Host cytoplasm Host endoplasmic reticulum. Note=nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes {ECO:0000250|UniProtKB:P0C6X9} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. NSP15 is a Mn2+-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.
References
Gorbalenya. bioRxiv: 2020.;Hui et al. Int J Infect Dis. 2020;91:264-266.;;;;;;;;;
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